Mouse models of age-related mitochondrial neurosensory hearing loss
نویسندگان
چکیده
منابع مشابه
Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss
Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, t...
متن کاملMitochondrial DNA haplogroups and age-related hearing loss.
OBJECTIVE To determine whether variants of the mitochondrial genome influence the risk of developing age-related hearing loss (ARHL). DESIGN Cross-sectional study. SETTING Eligible participants were noninstitutionalized permanent residents 49 years or older identified in a door-to-door census of 2 suburban postcode areas, west of Sydney, Australia. PARTICIPANTS The Blue Mountains Hearing ...
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We report mild-to-moderate neurosensory hearing loss and severe childhood autosomal recessive muscular dystrophy with adhalin-deficiency in two siblings from a Bulgarian sibship of Turkish origin. Microsatellite analysis excluded linkage to the adhalin gene, mutations of which cause limb girdle muscular dystrophy (LGMD) 2D, but was compatible with linkage to the gene locus of LGMD 2C on chromos...
متن کاملEvaluation of Age-Related Hearing Loss
Age-related hearing loss (presbycusis) is characterized by an increased hearing threshold and poor speech understanding in a noisy environment, slowed central processing of acoustic information, and impaired localization of sound sources. Presbycusis seriously affects the older people's quality of life. Particularly, hearing loss in the elderly contributes to social isolation, depression, and l...
متن کاملAge-related hearing loss: biological aspects
Presbycusis is one of the most prevalent neurodegenerative diseases of aging caused by changes in peripheral (cell loss in organ of Corti, spiral ganglion and stria vascularis) and central auditory systems (consequent to peripheral modifications or due to changes in the neurobiologic activity underlying central processing of auditory informations) [1]. Consequences are reduced sensitivity, tuni...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2013
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2012.07.004